Each 'bird's nest' in the image a single worm's trajectory through the shape space defined by three eigenworms (colour indicates position in the fourth dimension).

Publications

Google Scholar Profile

EE Keaveny, AEX Brown
Predicting path from undulations for C. elegans using linear and nonlinear resistive force theory
Physical Biology 14:025001 (2017)
[Abstract] [pdf]
[Code on GitHub]

A Gomez-Marin, GJ Stephens, AEX Brown
Hierarchical compression of C. elegans locomotion reveals phenotypic differences in the organisation of behaviour
Journal of the Royal Society Interface 13:20160466 (2016)
[Abstract] [pdf]
[Code on GitHub]

B Gyenes, AEX Brown
Deriving shape-based features for C. elegans locomotion using dimensionality reduction methods
Frontiers in Behavioral Neuroscience 10:159 (2016)
[Abstract] [pdf]

RF Schwarz, R Branicky, LJ Grundy, WR Schafer, AEX Brown
Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion
PLOS Computational Biology 11:e1004322 (2015)
[Abstract] [pdf]
[Code on GitHub]

Y Koren, R Sznitman, PE Arratia, C Carls, P Krajacic, AEX Brown, J Sznitman
Model-Independent Phenotyping of C. elegans Locomotion Using Scale-Invariant Feature Transform
PLOS ONE 10:e0122326 (2015)
[Abstract] [pdf]

EI Yemini, AEX Brown
Tracking single C. elegans using a USB microscope on a motorised stage
Methods in Molecular Biology 1327:181 (2015)
[Abstract] [pdf]

E Yemini, T Jucikas, L Grundy, AEX Brown*, WR Schafer*
A database of C. elegans behavioral phenotypes
Nature Methods 10:877–879 (2013)
[Abstract] [pdf]
Coverage: [Open Helix blog]

AEX Brown, E Yemini, L Grundy, T Jucikas, WR Schafer
A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion
Proc. Nat. Acad. Sci. USA 110:791-796 (2013)
[Abstract] [pdf]
Coverage: [F1000 (rated exceptional)] [Nature Methods highlight]
[Code on GitHub]

CA Russell, JM Fonville, AEX Brown, DF Burke, DL Smith, SL James, S Herfst, S van Boheemen, M Linster, EJ Schrauwen, L Katzelnick, A Mosterín, T Kuiken, E Maher, G Neumann, ADME Osterhaus, Y Kawaoka, RAM Fouchier, DJ Smith
The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host
Science 336:1541-1547 (2012)
[Abstract] [pdf]
Coverage: [Science News & Analysis] [Wired]

F Rehfeldt, AEX Brown, M Raab, S Cai, AL Zajac, A Zemel, DE Discher
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells
Integrative Biology 4:422-430 (2012)
[Abstract] [pdf]

AEX Brown, WR Schafer
Unrestrained worms bridled by the light
Nature Methods 8:129-30 (2011)
[Abstract] [pdf]

A Zhmurov, AEX Brown, RI Litvinov, RI Dima, JW Weisel, V Barsegov
Mechanism of fibrin(ogen) forced unfolding
Structure 19:1615-24 (2011)
[Abstract] [pdf]

PK Purohit, RI Litvinov, AEX Brown, DE Discher, JW Weisel
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks
Acta Biomaterialia 7:2374-2383 (2011)
[Abstract] [pdf]

A Zemel*, F Rehfeldt*, AEX Brown, DE Discher, SA Safran
Optimal matrix rigidity for stress-fiber polarization in stem cells
Nature Physics 6:468-473 (2010)
*contributed equally
[Abstract] [pdf]

K Rajagopal, A Mahmud, DA Christian, JD Pajerowski, AEX Brown, SM Loverde, DE Discher
Curvature-Coupled Hydration of Semicrystalline Polymer Amphiphiles Yields flexible Worm Micelles but Favors Rigid Vesicles: Polycaprolactone-Based Block Copolymers
Macromolecules 43:9736–9746 (2010)
[Abstract] [pdf]

CC Krieger, N Bhasin, M Tewari, AEX Brown, D Safer, HL Sweeney, DE Discher
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: Mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics
Cytoskeleton 67:796-807 (2010)
[Abstract] [pdf]

A Buxboim, K Rajagopal, AEX Brown, DE Discher
How deeply cells feel: methods for thin gels
Journal of Physics: Condensed Matter 22:194116 (2010)
[Abstract] [pdf]

A Zemel, F Rehfeldt, AEX Brown, DE Discher, SA Safran
Cell shape, spreading symmetry and the polarization of stress-fibers in cells
Journal of Physics: Condensed Matter 22:194110 (2010)
[Abstract] [pdf]

AEX Brown and DE Discher
Conformational Changes in Cell and Matrix Physics
Current Biology 19:R781-R789 (2009)
[Abstract] [pdf]

AEX Brown, RI Litvinov, DE Discher, PK Purohit, JW Weisel
Multiscale Mechanics of Fibrin Polymer: Gel Stretching with Protein Unfolding and Loss of Water
Science 325:741-744 (2009)
[Abstract] [pdf]
Coverage: [Eurekalert] [NPR]

AEX Brown*, A Hategan*, D Safer, YE Goldman, DE Discher
Cross-correlated TIRF/AFM reveals Asymmetry in Self-assembled Synthetic Myosin Filaments
Biophysical Journal 96:1952-1960. (2009)
*contributed equally
[arXiv] [Abstract] [pdf]

IM Kulic, AEX Brown, H Kim, C Kural, B Blehm, PR Selvin, PC Nelson, VI Gelfand
The Role of Microtubule Movement in Bidirectional Organelle Transport
Proc. Nat. Acad. Sci. 105:10011-10016 (2008)
[Abstract] [arXiv] [pdf]

AEX Brown, RI Litvinov, DE Discher, JW Weisel
Forced Unfolding of Coiled-coils in Fibrinogen by Single Molecule AFM
Biophysical Journal - Letters. 92:L39-L41. (2007)
[Abstract] [PubMed Central] [pdf]
Coverage: [Eurekalert]

A Brown, I Skanes, MR Morrow
Pressure Induced Ordering in mixed-lipid bilayers
Physical Review E 69:011913. (2004)
[Abstract] [pdf]

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